Paul... Ron & Gary have the flick. I've creeped mine around 90-95+ a couple of times but prudence and wanting to keep my 1776 intact until I go with a 2007/17 or 2110 plays in there! I think an IM would be a better platform for 90+ driving.
The true advantage of a 3:88 comes with more moderate freeway, highway, interstate cruising. Less work on the engine to accomplish the same thing with a 4:12. Per Jake I am putting on CHTs to monitor head temps, but I have to say I have been running 3 years and 19,000 miles with a 3:88 and a 1776cc at sustained 70-80 mph runs (more on the 70-75 side)and still have a nice tight running little 1776. That external oil cooler and fan do help, also the sump. I just ordered CHTs for this and any future engines though... so I can moniter head temps per Jakes advice. I guess the trick is to have a combo built that runs cool at the heads...
Back to high speed runs and the need for.... lets face it, unless you have a perfect road with little traffic, doing 100mph plus sustained (heavy on the sustained) is a high risk in most cars, especially a light Speedster Replica. My wife's Acura 3.2TL is built for interstate ass kicking, and still at 110-120 I am very wary... the car is better than the roads and the traffic I have to work through. I just sold a 3rd gen RX-7 Turbo, and past 125 there just wasn't a road out there worth dying on to see where she would peak. My point? Whether you go with a 4:12/3:88/3:44 your pick should be centered on where you want the max punch... and that takes a engine and R/P combo that meets that expectation. Also, forget high speed runs above 100+ in a pan car... unless you have a death wish. It can be done, but for how long? Think mid level punch... where you can REALLY use it, like side by side in traffic with that rice rocket and you want the juice to hit the gap.
ME? I like the 3:88, but would like an engine that pulls more torque on the low end.... just for grins at stoplights. Now at 2500-4500 Rpms in 3rd and 4th, my 1776 pushes nicely, but not as well as I want. When the time comes I will sit with a builder and explain what I am looking for and let them meet my needs.
So, for me a 2007/17 or 2110 built right, in a good daily driver mode, with a 3:88, oil-cooler and a good stable pan car may be the best bet short of popping the dough for an IM Speedster with a 901 and a nice 2110 or TIV. Someday I may do that... in the interim I'm keping my nice 1776 intact.
I'm no expert though... there are many on this net that can give you the tech why's and wht not's. I'm just a driver who works on his own car as much as I can, because that's half the fun.... Jim