Thanks for the replies. I made a quick sketch below showing the removable section I have in mind. Excuse the quality as I just freehanded it on my iPad.
More details:
No removable back glass or clear plastic like early 911 Targas. A roll bar (rectangular?) at the B pillar location and a roll bar or steel reinforcement around the windshield. The targa top and roof area around will be metal or metal-backed for the interior clamps and reinforcement. The targa top front and back would have ridges that fit into metal channels. You could possibly embed a sunroof in the targa top also.
What do you think?
What you are proposing would be a huge undertaking, and would likely either rattle or leak badly enough that the advantage over a coupe would be lost.
If you're looking for encouragement, we can do that-- we've all got our particular brand of illness, and are always looking for somebody to use as a benchmark ("look at this guy baby-- I'm not THAT crazy"). Still, the heart wants what the heart wants-- and if this is your muse, it doesn't matter what any of us think. Go for it.
If you are looking for honest input, I'd agree with Wolfgang and Jim-- the sweet zone of "bang for the buck", targa-style open air roof in a coupe would be a sliding rag-top. If I wanted a coupe, I'd get one for sure. If I had a Ghia coupe, I'd want one for sure. If I had a Beetle coupe, I'd want one for sure. They open a car up as much or more than what you are proposing, plus they are a feature that other people would find desirable, should you ever decide to sell.
It's an interesting project that's never been done. Every time I've undertaken a "one of a kind" thing, I find out halfway in why nobody's ever done it. Forewarned is forearmed.