2-stroke exhaust tuning is for guys who can devote crazy amounts of time to it. The rest of us just buy expansion chamber kits from somebody else, and hope for the best.
4-stroke exhaust tuning is more of a balancing act than most of us understand. For example: the headers we run, for the way most of us use our cars should probably be built with shorter primaries, long collectors, and specific length (and diameter) pipes running into chamber mufflers. The practical problems can be summed up in a word: room. There is no room for all this, unless you are willing to hang the collector 6" out the back of the car, and pipe from there. If you turn the collector 90 deg (sidewinder) to get everything to fit, the primaries get longer automatically.
As a result, most of us end up with primaries longer than we'd like, and larger in diameter than would be good (to try to compensate for the long pipes). The collectors neck down too far from ideal so that it's not so important what comes after that.
I'm trying to get a custom sidewinder made (to clear a dry-sump pump) that has shorter, smaller diameter primaries (under 34", 1-5/8 for a big number 2332), with a larger collector (2-1/4" i/d). I'll build a tuned length pipe dumping into a large volume chamber (also built). I'll build the rest of the exhaust (with mufflers and all that) after that. That's a lot of bends and exhaust stuff from Summit.
Everything matters in determining what "should" work, from cam overlap to the size of the exhaust port in relation to the intake. What works for my cam may be nuts for yours. The science is close to absolute, but the application is a bunch of suppositions.
I'll let you know how it goes once I get the header.