If your hubs use lug nuts, no problem. But if you have lug bolts, taking a wheel off or putting it back on can be a wrestling mach. You have to support the wheel and tire with one hand, and unscrew (or screw in) the bolts with the other. And, if you have Wheel Skinz, you’ll need a third hand to hold it in place.
To make life easier, cut the heads off two 12 mm bolts, each about 80 mm long. When in place at the top of the hub they support the wheel (and Skinz) while you unscrew or screw in the lug bolts. It’s like having an extra hand.