I've got a little time here since it's 3:20 AM, but here's my experience FWIW:
I had a car with a 1776 and dual Weber 40 IDFs in 2000-2002. It never really ran right- I had one throat that wouldn't respond to any mixture adjustment. I thought it was a plugged idle jet, but I took it apart/blew it out MANY times, and never could get it to respond. I suspect there was a vacuum leak, but I never could determine the source.
I had a JPS with an identical Serranno 1776, except it was equipped with "baby Webers"-- dual ICTs (with a CB linkage/air-cleaner kit) from 2002-2005. It was a complete joy. Single barrel, easy to set-up, no muss, no fuss-- never skipped a beat.... but only able to support a mild 1776-- just not very big.
I did my own engine (a 2110) for the car I've got now. I really liked the simplicity of single barrel carbs, and since I couldn't get the ICTs any bigger, I called A J Sims on the recommendation of many guys on this forum, and bought the whole enchilada from him- a set of heavily modified, enlarged 46 mm Kadrons with ALL the extra goodies- bushed shafts, float vent, welded/port-matched manifolds, yada, yada, yada. I also bought his heads, his junk vacuum advance distributor, used his cam recommendations, and built the whole engine around what he said would work beautifully.
It never ran right, and it was not for any lack of trying. The needle and seat leaked by and the whole thing flooded badly no matter what I did. I lowered the fuel pressure until I couldn't keep it running, I sent the carbs back for A J to look at/work on. Nothing helped.
Finally, I called Art Theron at ACT in Salt Lake. He kindly told me to take the Kads off, and put on a set of Dellorto 40s, which I purchased from him, along with the CB linkage/air-cleaner/manifold (port matched) kit. I put on a 009 distributor, and put all $1000 worth of A J Sims stuff in a box on my shelf.
This was two years ago, and I've never touched the carbs since I took them out of the box, and set them up on my engine. They work amazingly well. I was fully ready to go with EFI, because I didn't think carbs could ever work this well. EFI comes with it's own set of requirements (namely.... build the whole system yourself, or be prepared to go without an O2 sensor, and defeat the whole purpose). I'm hoping to build a 2332 this winter with all the goodies, and I just bought a set of 48 Dellortos on ebay. I'm in love.
Your mileage may vary. Plavex isn't for everyone. If you experience nausea, shortness of breath, or double vision-- see your doctor right away.
Good luck.