Adam, there are two likely points of interference on your car (that I can think of off-hand besides those mentioned above). The cooling fan assembly may hit your deck lid. That's probably your most likely contact area. The further you can put the engine toward the passenger compartment, the better this fit issue will be.
The CIS system is fairly tall and will require a return line. Line is not a big deal, but the airbox and plenum are tall. Check that too. Or go with carbs. On the 3.0 you can use 40mm webers, 40mm PMO's or even Zeniths. Don't knock the Zeniths, they are cheap because everyone thinks the webers are hugely better, but for street driving the zenith is arguably a better carb. Budget $600-$1000 for used webers, $200-$300 for used Zeniths (good condition). Use short stock manifolds or the PMO "short" manifolds.
The 3.0 engine ignition system will not trigger most tachs. Budget for that. Either a 3.0 tach or signal amplifier or have your tach redone and obviously calibrated for the six.
The 915 transmission is HUGE compared to a VW. The 901 transmission, though far less robust is somewhat smaller than the 915 and is capable of decent life behind a 3.0 as long as you don't act like a taco-brain in 1st gear. 1st gear is unsupported in a 901 transmission.
I've never seen a 911 engine in a pan based speedster. But I have seen 911 engines in VW bugs so obviously it "can" be done. By "can" I mean with skill, craftsmanship and money.
As far as maintenance goes, the older CIS systems can be somewhat troublesome to repair. They run great, and then drive people nuts when something goes wrong. Usually, people find vacuum leaks and fix them or just start swapping parts (like Warm Up Regulator) until they get it fixed. Yuck. If yours has problems, I would highly recommend swapping to carbs. The throttle response is significantly better and the troubleshooting is pretty breezy.
Also, check the headstuds (especially the lower ones closest to the flywheel) on the 3.0. You don't want to go thru this very difficult build only to find you have broken headstuds and need to rebuild the engine.
*also* budget for brake and suspension upgrades. Never hot-rod a car without doing that first.
angela