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I remember a full load of brand new Volvos was on a container ship, and almost all were lost in the deep.
You would think that with an almost never ending supply of water a fire like that could be contained unless what's fueling the fire can't be extinguished by water.
Even though engineers have developed new, fire-retardant chemicals that are effective in fire suppression, almost all large fires are still extinguished by water. Fires at sea have inherent problems that are extremely difficult to overcome, with the main one being lack of trained personnel.
Cockpit problems are the main cause of shipboard fires. Small fuel or lube oil leaks are ignored and eventually ignite from heat generated by engines/generators, exhaust, etc. Once the fire spreads to cargo, the fire is likely out of control.
Container ships offer their own set of access problems, since shipowners pack cargo as tightly as possible, both on deck and below. Dangerous cargo is frequently mixed with general cargo, and most containers are not inspected.
Anyone who has spent time on board a vessel at sea can tell you that the smell/sight of smoke really gets your attention.