There's a longer/better answer here.
If you are involved in any discussion of anything for a certain length of time in the "ACVW online community", someone will eventually get back to "the sainted German engineer" who designed this or that perfectly, so that no modification could ever be an improvement. The entire oiling system is a Rube Goldberg contraption that relies on viscosity to determine oil temperature, etc., but discussing it in a rational manner with a true believer is a fool's errand. The cooling system is sacrosanct, it's the third rail of the subway-- touch it and die.
The lack of a rear seal will garner all kinds of ridiculous defenses from this crowd. "The giant hole RIGHT NEXT TO the oil level won't blow oil if the rings are tight, etc. It's fine just the way it is. Perfect, in fact."
When it was being designed 80 years ago, it all boiled down to economics-- in a size tiny engine in a time when oil leaks were pretty much just par for the course, getting away with a slinger and a pulley with oil grooves was "good enough". It wasn't ever intended to be the one true path, but don't say that in Samba-world.
Anyhow, the case is pretty small. Increasing the stroke makes it even tighter inside, to the extent that in some combinations the camshaft must be clearanced to miss the crankshaft. There's a lot of pumping action inside that case, creating a lot of turbulence. Each quarter revolution of the crank pushes a piston down into the case, creating a pressure wave-- of course, there is a piston going up as well, but the oil vapors inside the engine are moving around a lot, even with a super-tight engine. Increasing the bore and/or stroke increases the volume of this displaced air/vapor.
That would be enough, by itself, to warrant a seal. However, throw in the fact that no engine is 100% tight-- even race engines have 5-ish% leak-down. A standard "good enough" engine build will have more than that (a lot more). Keep in mind, these engines don't even have valve seals. With the case being pressurized by blow-by, and the entire mixture being pumped by the action of the pistons, it's kind've amazing that the thing doesn't blow oil worse than it does.
That's why we need case vents, etc. A decent PCV system would greatly reduce the pressure inside the case, but I'll be a monkey's uncle if anybody seems to be trying to make that work. Everybody seems to be happy just blowing oil like it's 1935. A seal helps, but it doesn't fix it.
I hate oil leaks-- I really, really hate them. I have a seal. I also dry-sumped my engine, in no small part because of my inclination to "THAT ought to do it" overkill. Drawing a vacuum on the case is a pretty good way to get rid of the pressurization. I've also got a breather box with about 3 gallons of capacity. To my way of thinking, the box has to be at least equal to the volume of the case to actually do anything. I'm running 1/2" hoses to it. It's not vented. I draw off the top of the (sealed) box, and run to a Moroso check-valve and a Bernoulli tube in the exhaust to draw a vacuum on the entire box.
It's pretty oil-tight, but it took redesigning the entire thing to get it that way. In more pedestrian engines (like my 2110), bolting on an extended sump and running the thing a 1/4" low on oil (don't freak out-- the pick-up is in the sump) seems to keep the oil level away from the crank-pulley hole, and give the case a bit more volume. I seem to spray less running it that way. But maybe I'm just deluding myself.
So... the short answer is "Yes, it'll help keep the oil inside the engine. No, it won't (by itself) fix anything. But a seal is just a good idea (kind've like a remote oil cooler)". If something can't hurt, and can only help, why would we obsess over if "it's really needed"?
That's my story and I'm sticking with it. Your mileage may vary.