Darrell:
I have one of those 2110's and I love it. It runs a pair of Dellorto 40mm carbs, an Engle 120 cam, balanced crank, Berg 903DP headers (no heater boxes), lightened flywheel, magna-spark ignition and all that other stuff, along with stock cooling, and has a LOT of low to mid torque between 2,200 and 3,500 rpm. Only at the end of the Summer did I start to open it up at the top end when I finally got over 1,200 miles (although my mid-eleven-second-son tells me I was still babying it) and it is a whole different (and much hotter) engine over 4 grand when it starts to flow. I built it up myself, but it is heavily invested in CB Performance (the heads, carbs and some of the case work). I do not have hydraulic lifters, but I would be interested to talk with someone who successfully uses them, although it's too late for me to use them on this engine.
It doesn't leak (yet), seems to run cool (but I've now got a good temp thermometer in there so I'll know better this Summer), supposedly makes about 140 hp and, so far, has been super reliable but, hey, it's only got about 1,600 miles on it!!
It has more than enough power for what I want to do with it (I'm too old to go crusin for V-8's to kill but it ROCKS on twisty back roads!!) and I believe it should last for 100K miles or more.
I totally agree with Stan on the costs involved - he's right on the money, (no pun, there) as to build it yourself will cost you over $3,500, and probably $4K - $5K for a turn-key......not cheap. However, I'm constantly seeing posts here from folks who got a 1776 and now wish they had a 2110 or 2160 T4 (or bigger) or something like that, so why not start out with that to begin with? If I was gonna do it over, I would probably go the 2160 T-4 route and another beefy transmission, but I'm happy with my 2110 so far. Stan, Paul and Jim have some terrific insights (wish I could figure out a way to get to Knott's to visit with them!) so listen to them!
Cockpit Heat's gonna be an issue, unless you spring $600 - $1K for a new Gas heater, and then it's moot unless you live in a warm place where you won't need it. All the rest is personal preference.
Gordon