Everyone has their own hymnal when it comes to tuning Webers
What's on the first page of mine is what Anthony said about hot and cold.
I used to start it up in the driveway, wait until the oil temp needle was off the peg a bit, and dial everything in. I'd then jump in, and five miles down the road, it sounded like a paint mixer. I'd drive back home, dial it all in again, and set the idle back to 750.
The next time I started it, I had to feed it gas for a minute before it would idle, and those dad-blamed Webers were all messed up again.
It's easy to see why Webers (what most of us have) get such a bad rap in a world of always-perfect computer controlled engines. Remember, our carbs don't even have chokes. There's no way they're going to be happy when they're cold.
Now, like Anthony says, I don't even try to tune them unless they're good and warmed up - which means driving for at least 15 minutes - more in colder weather. You need to let the heat from the heads work its way up through the manifolds to the carb bodies and also let the engine compartment temp get up to where it is in normal driving.
After a while, all the bits and pieces (including the critical linkage) reach thermal equilibrium and only then is there any chance of your engine 'holding' a tune.
It's all a compromise to some extent. My ritual is to come back from a drive, set the mixture screws as lean as they'll go without popping, tweak the idle stops just a scosh to synch the two sides, then set the idle a little on the high side. I use 1000 or even 1100, which most people say is too high, but it always starts and idles no matter how cold it is without having to feed gas. When it's fifty degrees out, it may idle only at 500 or so from cold, and it sounds noticeably 'out of synch'. But after a few minutes at idle, without blipping the gas at all, it gradually works its way up to about 800 and it starts to come into synch. When it does, I drive off.
It still doesn't smooth out all the way for a few more miles, but it's nice to feel it come into tune as you drive rather than the other way around.
Like I said, everyone has their own hymnal and this one works for me. There's another church, on the other side of town - the SyncLinkopalians - whose hymns are even more in tune than mine.